Fig. 7: Stimulation-evoked movements in spinal cord transected animals.

a An awake, spinal cord transected (T10) animal is stimulated. b A limb propulsion movement is evoked from stimulation of a spinal electrode site (c3) while the animal is locomoting on a treadmill with unparalyzed forelimbs. c Stimulation of spinal electrode site (c0) evoked limb retraction. d Stimulation in cage with freely moving spinal cord injured animals. Middle plot illustrates the average voltage compliance at each region of the cage. Right plot illustrates movement trajectories (blue) measured over 2 hours. Green marks indicate points at which stimulation is compliant; red marks indicate uncompliant stimulation. e Freely behaving animal on a moving treadmill (conventions follow (d)). f Voltage compliances on individual trials over two 6-hour sessions and sessions recorded 25 and 28 days following device implantation. g Distributions of voltage compliances measured in three enclosures of increasing sizes: large cage (29 cm × 36 cm), treadmill (16 cm × 56 cm), small cage (18 cm × 36 cm).