Table 1 Patient demographics and antibiotic usage
Subject characteristics | Non-CDI n = 136 | CDI n = 33 | Non-CDI vs CDI P-value | Statistical test |
---|---|---|---|---|
Gender (Male) % | 64 (47.4%) | 18 (54.5%) | 0.563 | Chi-square6 |
Age, median years (IQR) | 68 (52-78) | 75 (55-83) | 0.181 | Mann–Whitney U7 |
Days hospitalisation, median (IQR) | 8 (5-13) | 9 (6-14) | 0.528 | Mann–Whitney U |
Prior hospitalisation1, n (%) | 83 (60.6%) | 27 (81.8%) | 0.079 | Chi-square |
Multiple hospitalisations1, n (%) | 56 (41.2%) | 17 (51.5%) | 0.144 | Chi-square |
Antibiotic and non-antibiotic medications | ||||
Any antibiotic, n (%) 2 | 116 (69.7%) | 23 (84.7%) | 0.084 | Chi-square |
Days antibiotic treatment, median (IQR)3 | 5 (3-9) | 4 (2-11) | 0.935 | Mann–Whitney U |
Number of antibiotic classes, median (IQR)4 | 2 (1–3) | 2 (1–3) | 0.835 | Mann–Whitney U |
Any PPI, n (%) | 94 (68.6%) | 26 (78.8%) | 0.336 | Chi-square |
PPI + antibiotics, n (%) | 81 (59.1%) | 19 (57.6%) | 0.139 | Chi-square |
Chemotherapy, n (%) | 26 (19.0%) | 7 (21.2%) | 0.978 | Chi-square |
Chemotherapy + antibiotics, n (%) | 22 (16.2%) | 4 (12.1%) | 0.823 | Chi-square |
Antibiotic classes2, n (%) | ||||
Aminoglycoside | 11 (9.5%) | 0 (0%) | 0.297 | Chi-square |
Carbapenem | 13 (11.2%) | 0 (0%) | 0.224 | Chi-square |
Cephalosporin | 60 (51.7%) | 16 (76.2%) | 0.061 | Chi-square |
Cyclic lipopeptide | 3 (2.6%) | 0 (0%) | 1.000 | Chi-square |
Fluoroquinolone | 9 (7.8%) | 3 (14.3%) | 0.337 | Chi-square |
Glycopeptide | 15 (12.9%) | 2 (9.5%) | 0.939 | Chi-square |
Clindamycin | 1 (0.9%) | 2 (9.5%) | 0.092 | Chi-square |
Macrolide | 18 (15.5%) | 2 (9.5%) | 0.704 | Chi-square |
Metronidazole | 33 (28.4%) | 6 (28.6%) | 1.000 | Chi-square |
Penicillin | 19 (16.4%) | 2 (9.5%) | 0.636 | Chi-square |
Penicillin β-lactamase (Oral) | 16 (13.8%) | 3 (14.3%) | 1.000 | Chi-square |
Penicillin β-lactamase (IV) | 42 (36.2%) | 8 (38.1%) | 1.000 | Chi-square |
Trimethoprim | 4 (3.4%) | 0 (0%) | 0.873 | Chi-square |
Tetracycline | 6 (5.2%) | 1 (4.8%) | 1.000 | Chi-square |
Other 5 | 1 (0.9%) | 1 (4.8%) | - | - |