Table 2 DNA methylation associated with T2D in the Islet T2D case-control cohort within genes differentially expressed in islets from T2D cases vs. controls that also associated with future T2D based on blood DNA methylation in the prospective EPIC-Potsdam T2D case-control study

From: Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes

 

Islet T2D case-control cohort

EPIC-Potsdam

DNA methylation

RNA-seq

Blood DNA methylation

CpG site

Absolute difference

P-value

Odds ratio

(95% CI)

P-value

Gene

P-value

Odds ratio

(95% CI)

P-value

cg05324789

−3.50%

3.2 × 10−4

0.77 (0.65−0.90)

0.0014

NKX6.2

4.3 × 10−5

0.43 (0.24−0.76)

0.004

cg20355381

−5.60%

4.4 × 10−7

0.63 (0.47−0.78)

3.1 × 10−4

CABLES1

1.2 × 10−4

0.56 (0.37−0.84)

0.006

cg15167202

−4.70%

6.8 × 10−4

0.85 (0.76−0.94)

0.0027

SYNPO

3.0 × 10−4

0.43 (0.20−0.94)

0.034

cg10339923

−8.30%

5.0 × 10−8

0.76 (0.66−0.86)

4.9 × 10−5

RHOT1

3.3 × 10−4

0.68 (0.47−0.97)

0.035

  1. For islet DNA methylation, both absolute difference (cases-controls) based on linear regression and odds ratios based on logistic regression are shown.
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