Fig. 1: Summary of genome-wide association studies (GWAS) in Africa and ancestral fractions for our dataset.

A Map showing populations across Africa where GWAS studies have been conducted for prostate cancer, and sample locations and sizes of African ancestry from the Human Genome Diversity Project (HGDP) and 1000 Genomes Project (1KGP) subset of gnomAD v3.12⁶⁷ (red circles). Mortality rates of prostate cancer from GLOBOCAN 2020 are shown in the bottom left bar plot, with the population size of men in the region indicated in brackets below the region name⁴. Study references: ^aCook et al.¹⁰, ^bHarlemon et al.¹³, ^cTindall et al.¹², ^dDu et al.¹¹. B Admixture plot (K = 5, cross-validation error = 0.162) which was replicated in 10 out of 10 runs, including 1003 Africans, 20 Europeans, 20 Chinese individuals from the HGDP and 1KGP subset of gnomAD with our dataset of 781 South Africans.