Fig. 4: Mutational patterns reveal mutagenic factors for cancer genomes. | Nature Communications

Fig. 4: Mutational patterns reveal mutagenic factors for cancer genomes.

From: Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma

Fig. 4

a Proportion of single nucleotide substitutions (SBS) assigned to the COSMIC mutational signatures (v3.2). b Number of somatic mutations assigned to the APOBEC-associated signatures (SBS2 and SBS13) and the reactive oxygen species (ROS)-associated signature (SBS18) for each subtype in the upper and lower panels, respectively. c Proportion of indels (ID) assigned to the COSMIC mutational signatures (v3.2). Upper part of the graph, number of somatic mutations assigned to the ID6. Arrows indicate two cases with a high abundance of the ID6 signature. d Association between SV occurrence and BRCA2 mutation status. The number of deletions and the proportion of shorter (<50 kb) deletions are represented in the graph. e Tobacco-related mutational signatures and smoking history of each case. Comparison of the number of somatic mutations assigned to tobacco-related signatures (SBS4, ID3, and DBS2) between smokers and non-smokers in each adenocarcinoma subtype. The p-values were calculated by Wilcoxon rank sum test (two-sided, no multiple comparison adjustments) and are shown in the top of each graph. n.s. not significant. Source data are provided as a Source Data file for (a, b, c, d and e).

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