Fig. 5: Epigenomic aberrations in early and advanced lung adenocarcinoma. | Nature Communications

Fig. 5: Epigenomic aberrations in early and advanced lung adenocarcinoma.

From: Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma

Fig. 5

a Genome-wide methylation status of each case. The distribution of DNA methylation rates in each 50 kb genomic window is shown in the violin plot. DNA methylation rates of each normal counterpart shown as red dot plots. b Median genome-wide DNA methylation rates. The p-values were calculated by Wilcoxon rank sum test (two-sided, no multiple comparison adjustments). c An example of DNA hypomethylation. Unmethylated and methylated cytosine bases in CpG sites are colored in blue and red, respectively. d Association between differences in median genome-wide methylation rates (50 kb windows) from normal counterparts and number of copy number events and insertions. Each plot represents one case. Spearman correlation coefficient and p-values (two-sided, no multiple comparison adjustments) are shown in the inset. e DNA methylation patterns of LINE-1, Alu, and SVA in each subtype. f DNA methylation patterns of CpG islands, CpG shores, promoters, and possible enhancers in each subtype. Source data are provided as a Source Data file for (b, d, e and f).

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