Fig. 7: Haplotype-resolved genomic, epigenomic, and transcriptomic aberrations in early and advanced lung adenocarcinoma. | Nature Communications

Fig. 7: Haplotype-resolved genomic, epigenomic, and transcriptomic aberrations in early and advanced lung adenocarcinoma.

From: Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma

Fig. 7

a Number and proportion of somatic point mutations assigned to haplotypes. b The number and proportion of SVs assigned to haplotypes. c Number and proportion of mutation-enriched and haplotype-biased regions. HP: haplotype. d An example of mutation-enriched and haplotype-biased regions in an AIS case. The graph shows all mutation-enriched windows in this case (top panel). The p-values were calculated by hypergeometric test using R function phyper (one-sided, adjusted by Bonferroni correction). List of somatic mutations in a mutation-enriched and haplotype-biased region (middle panel). The 96 substitution patterns of somatic mutations in the mutation-enriched and haplotype-biased regions (bottom panel). e An example of the somatic mutation pairs for which long reads directly resolve the occurrence order. Source data are provided as a Source Data file for (a, b, c and d).

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