Fig. 8: Clonal architecture of early adenocarcinoma. | Nature Communications

Fig. 8: Clonal architecture of early adenocarcinoma.

From: Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma

Fig. 8

a Mutation clusters (clones) in all cases. The dots represent each clone and their size indicates the proportion of somatic mutations in the clone. The number of clones is shown in the bar graph. b Validation of estimated clone structures using long reads. The occurrence order of a total of 92 SNV pairs was directly resolved by long reads. The 61 SNV pairs were assigned to the same single clone population of the PyClone result. The breakdown (consistent/discrepant with the evaluation by the long reads) of the 31 SNV pairs assigned to the different multiple clones of the PyClone result were represented in the bar chart. c Estimated clone structures in two cases, TSU-02 (AIS Noguchi type B) and L07K233 (Lepidic-Ad), which harbored FOXA2 mutations. CCF cancer cell fraction. d Two candidates of clone structures in case TSU-01 (AIS Noguchi type B). e Summary of genome-wide and multi-modal characterization of lung adenocarcinomas from early to advanced cases. Source data are provided as a Source Data file for (a).

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