Fig. 2: MtbFtsEX exhibits unusual ECD domain conformation compared to other Type VII ABC transporters.
From: Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis
a The surface representations of the ECD/PLD domains are shown (top-down view), with the upper lobe of the ECD/PLD colored yellow and the lower lobe colored in light green. In MtbFtsEX, the two lower lobes of the ECD face in opposite directions, whereas in AaMacB (PDB code: 5LIL) and EcLolC (PDB code: 7ARK), the two lobes face to each other. UL upper lobe, LL lower lobe. b Structural comparison of ECD/PLD domain in three Type VII ABC transporters with structures available: MtbFtsEX, AaMacB, and EcLoLC. The structures are represented by ribbon (front view). c Structural comparison of an ECD/PLD monomer, along with the connecting hinge region, between MtbFtsEX, AaMacB, and EcLoLC. The hinge region from TM1 in MtbFtsEX exhibits a large kink conformation, while the corresponding regions in AaMacB and EcLoLC maintain a straight conformation, leading to a different orientation of the connecting ECD monomer. The hinge region from TM1 is highlighted in red.
