Fig. 6: Biodistribution and anti-tumor efficacy of the nanoparticles.
From: Near-infrared light-triggered prodrug photolysis by one-step energy transfer
a Representative IVIS fluorescence images of the mice after injection of free DiR and DiR NPs within 24 h. White dashed circles indicate tumor areas. b Quantitative analysis of biodistribution in major organs and tumors determined by IVIS. Tu, He, Lu, Sp, Li, and Ki represent tumor, heart, lung, spleen, liver, and kidney, respectively. Data are presented as mean ± SD, n = 3 mice per group. c Schematic illustration of the treatment schedule. Created with MedPeer (www.medpeer.cn). d Photograph of a mouse irradiated with NIR light at the tumor site. e, f Concentrations of BC and Cb in tumors and organs at 24 h after intravenous administration of Os/BC NPs with/without light irradiation on tumors. Data are presented as mean ± SD, n = 3 mice per group. g Photograph of tumors resected at Day 13 after different treatments. h Tumor volumes of each group. i Representative H&E staining of tumor sections of different treatment groups. Scale bar: 200 μm. Light irradiation: 690 nm, 300 mW/cm2, 10 min. j Body weight of each group. In h and j, data are presented as mean ± SD, n = 5 mice per group. Statistical differences in b, e, f, h were analyzed by two-tailed Student’s t-test. Source data are provided as a Source Data file.
