Fig. 2: Electrophysiological recordings.
Current traces for Aβ1-42 (a), Aβ1-40 (b), AβpE3-42 (c), and AβpE3-40 (d) in shorter time scale reveal the single channel conductance behaviors. Discrete conductance levels have been marked with notation Lc, i.e. closed state, and Lo1, Lo2, …, corresponding to multiple open state levels. These levels have been assigned to include maximum number of points at a particular conductance level. In all cases except panel c (AβpE3-42), the hold voltage was +50 mV. For AβpE3-42, -50 mV was chosen as the step-like conductance activity was more distinguishable compared to the +50 mV trace. Membrane lipid composition was the same as in Fig. 1, and the buffer was 1 M KCl + 10 mM HEPES, pH 7.4. At least five independent experiments have been conducted with similar results.
