Fig. 4: Cryo-EM structures of lipidic L2 and L3 Aβ40 fibrils.
From: Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)
a, b Cross-sections of the cryo-EM maps of the L2 (a) and L3 (b) Aβ40 fibrils, with lipid densities indicated by a yellow arrow. c, d Overlay of a sharpened high-resolution map and an unsharpened, 4.5 Å low-pass filtered density is shown in gray for the L2 (c) and L3 (d) Aβ40 fibrils. The close-up view shows areas with pronounced lipid densities, with ring-shaped densities in the cryo-EM cross-sections showing the lipid head groups, while the rod-shaped densities show the lipid acyl chains. Supplementary Fig. 8b, c shows the sharpened high-resolution maps at different isosurface levels.
