Fig. 2: Rpd3S modules and Sin3-Rpd3 interactions.
From: Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex
a Overview highlighting the Rpd3S core module with Rpd3, Sin3, Rco1A, and Eaf3A, and the auxiliary module with Rco1B, Eaf3B, and Ume1. b Sin3 encircles Rpd3 and interacts with the HDAC fold of Rpd3 via multiple domains. c Detailed interaction of Sin3 via residues Sin3 residues Glu811 and Glu812 with Rpd3 residues Lys41, Arg280, and Arg316 reveals allosteric activation of Rpd3 by Sin3. d View as in b with 180° rotation. e The Sin3 gating loop binds the Rpd3 HDAC fold.
