Fig. 1: Overall structure of the OCA–OR52cs–Gs–Nb35 complex.
From: Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family
a Dose-response curves of OR52cs for carboxylic acid odorants of different lengths; hexanoate (red), heptanoate (orange), octanoate (OCA) (black), nonanoate (green), decanoate (blue), undecanoate (purple), and dodecanoate (brown). Each data point represents the mean ± standard error of the mean (S.E.M.) from n = 3 independent experiments except for OCA (n = 5 independent experiments). b Cryo-EM map (left) and model (right) of the OCA–OR52cs–Gs–Nb35 complex. OR52cs, Gαs, Gβ1, Gγ2, and Nb35 are colored green, cyan, yellow, magenta, and light-gray, respectively. OCA is shown as pink sticks, with the surrounding density map displayed at a threshold of 0.336 in a zoomed view.
