Fig. 5: Comparison of the apo and active states of OR52_cs.

a An overlay of the apo (orange) and active (green) states of OR52_cs is presented in the side (left), extracellular (upper right), and intracellular (bottom right) views, with movements of the TMs highlighted by red arrows. Y254^6.48 of the FY^6.48xP motif that act as a pivot and R265^6.59 are shown as sticks. b Residues participating in interactions that stabilize the extracellular segments of TM6 and TM7 are shown as sticks. Polar interactions are represented as dashed blue lines. The rotation of R265^6.59 upon activation is indicated by a red arrow. The side chains of F261^6.55, H264^6.58, and R265^6.59 are unresolved in the apo structure. c Interactions between F258^6.47 and V209^5.47 and between Y282^7.41 and Y180^45.49, which are observed only in the active state, are shown, with the rotation of F258^6.47 and Y282^7.41 upon activation, indicated by red arrows. OCA is not shown for clarity. d The interaction network of TM3-TM6-TM7 formed upon receptor activation is shown. e Conservation of key residues stabilizing the active conformation, highlighted in (b–d), is depicted using WebLogo 3.