Fig. 4: Structural basis of Fab recognition of gluten pHLA-DQ2.5. | Nature Communications

Fig. 4: Structural basis of Fab recognition of gluten pHLA-DQ2.5.

From: Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease

Fig. 4

a Structures of Fab DQN0344AE02 and HLA-DQ2.5:DQ2.5-glia-α1a, (b) Fab DQN0344AE02 and HLA-DQ2.5:DQ2.5-glia-α2, (c) Fab DQN0385AE01 and HLA-DQ2.5:DQ2.5-glia-γ2, and (d) Fab DQN0385AE02 and HLA-DQ2.5:DQ2.5-hor-3a. Fab colors, and peptide are colored as indicated. e Interactions of the Fab DQN0344AE02 with HLA-DQ2.5 α and β chains. f Interactions of Fab DQN0385AE02 with HLA-DQ2.5 α and β chains. Fab residues directly interacting with HLA-DQ2.5 allotype specific residues are represented as sticks with single-letter codes, and HLA-DQ2.5 allotype specific residues directly interacting with Fab are represented as thicker sticks with bold three-letter codes. Cyan colored dotted lines represent hydrogen bonds and salt bridges, and other colored dotted lines represent van der Waals interaction.

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