Fig. 5: Interaction of Fabs with HLA-DQ2.5 loaded gluten peptides. | Nature Communications

Fig. 5: Interaction of Fabs with HLA-DQ2.5 loaded gluten peptides.

From: Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease

Fig. 5

a Interactions of DQN0344AE02 with HLA-DQ2.5:DQ2.5-glia-α1a. Fab and peptides residues are represented as sticks with single-letter codes. Cyan colored dotted lines represent hydrogen bonds and salt bridges, and ocher colored dotted lines represent van der Waals interaction. CDRs, FR, and peptide are colored as indicated. b Interactions of DQN0344AE02 with HLA-DQ2.5:DQ2.5-glia-α2. Box insert: Key DQN0344 interactions to P3, P5 of DQ2.5-glia-α2 and surrounding HLA-DQ2.5 residues. HLA-DQ2.5 allotype specific residues directly interacting with Fab are represented as sticks with three-letter codes. c Interactions of DQN0385AE01 with HLA-DQ2.5:DQ2.5-glia-γ2. d Interactions of DQN0385AE02 with HLA-DQ2.5:DQ2.5-hor-3a. Box insert: Key DQN0385 interactions to P5-P8 of DQ2.5-hor-3a and surrounding HLA-DQ2.5 specific residues. e Sequence motif of all HLA-DQ2.5 restricted pathogenic gluten core 9-mer epitopes are taken from ref. 14. f Sequence motif of those HLA-DQ2.5 restricted pathogenic gluten core 9-mer epitopes that have non-bulky residues (Pro or Leu) at P5. g Sequence motif of those HLA-DQ2.5 restricted pathogenic gluten core 9-mer epitopes that have bulky residues (Gln or Phe) at P5. Sequence logos are generated by WebLOGO.

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