Fig. 1: Method spectrum and molecular features of the MBEN patient cohort. | Nature Communications

Fig. 1: Method spectrum and molecular features of the MBEN patient cohort.

From: Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage

Fig. 1

a Visual summary of all methods that were applied to investigate the MBEN cohort. b t-SNE depicting a clustering of the MBEN cohort (n = 9) with a reference cohort of 391 molecularly characterized MBs. All nine samples clustered with the SHH-subtype. c Pie chart summarizing the alterations in the SHH-pathway that were detected using DNA panel seq. d H.E. staining showing the two characteristic histological components of MBEN. The black asterisk marks the internodular component, whereas the black arrow points towards a tumor nodule. All nine cases were histologically diagnosed as MBEN. Scale bar = 300 µm. e Representative coronal MRI image in an MBEN patient showing a large cerebellar mass with grapevine-like appearance. In order to design Fig. 1a, the two images “genomesequencer9” (by DBCLS, licensed under https://creativecommons.org/licenses/by/4.0/), and “multiwell-plate-3d” (by Servier, licensed under https://creativecommons.org/licenses/by/3.0/) from the database https://bioicons.com were used. Source data are provided as a Source Data file.

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