Fig. 2: Substitution mutational signatures in Japanese RCC cases.
From: Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort
a Signal-mutational signatures of 128 Japanese RCC cases. The heatmap represents clinical information and single nucleotide polymorphisms (SNPs) in ALDH2 and ADH1B. REF and ALT represent reference and alternative alleles, respectively. BMI, mass index. The upper and lower histograms show the relative and absolute values of the mutational signatures, respectively. SBS, single-base substitutions. b A cartoon of nephron and features of RCC subtypes. Glom glomerulus, PCT proximal convoluted tubule, LH loop of Henle, TAL thick ascending limb of Henle’s loop, DCT distal convoluted tubule, CCD cortical collecting duct, MCD medullary collecting duct. Scale bars in HE, 50 μm. Source data are provided as a Source Data file.
