Fig. 2: Atroposelective P(III)-directed C–H olefination of biaryl phosphines with alkynes.
From: Atroposelective hydroarylation of biaryl phosphines directed by phosphorus centres
Reaction conditions: [Ir(cod)Cl]2 (5 mol%), L3 (11 mol%), 1 (0.2 mmol), 2 (1.0 mmol) in 2 mL of dry toluene at 70 °C for 72 h under argon; ee was determined by chiral HPLC analysis; Isolated yield. aAt 75 °C. bAt 90 °C.
