Fig. 2: IgM N-glycan profile stratifies cohorts of nonsevere from severe trajectory COVID-19 patients.
From: IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
a IgG N-glycans from healthy control (n = 2), day 4 trajectory 1–3 (n = 12), and day 4 trajectory 4&5 (n = 10) cohorts. N-glycans are graphed as grouped classes––see supplemental Fig. 4 for a full list of N-glycans and N-glycan grouping. b IgM N-glycan profiles from cohorts of healthy control (n = 2), day 4 trajectory 1–3 (n = 12), and day 4 trajectory 4&5 (n = 10) hospitalized COVID patients. Data are presented as mean values +/– S.D. See Fig. 1c for a detailed explanation of N-glycan classes. c IgM mannosylated N-glycans from non-severe compared to severe COVID-19. A summation of the indicated mannose/hybrid N-glycan sub-groups are graphed to the right. IgM N-glycan classes are graphed as mean +/– S.D. Statistical significance was determined using two-sided unpaired t-tests *p < 0.05, **p < 0.01, ***p < 0.001. Source data are provided as a Source Data file.
