Fig. 7: Flux balance analysis reveals the effects of AMR-conferring genes on metabolite yields and reaction fluxes and shows a great overlap of E. coli and S. enterica pathways enriched with genes correlated to AMR. | Nature Communications

Fig. 7: Flux balance analysis reveals the effects of AMR-conferring genes on metabolite yields and reaction fluxes and shows a great overlap of E. coli and S. enterica pathways enriched with genes correlated to AMR.

From: Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China

Fig. 7

Undirected graph network showing, for both the S. enterica GSM model (STM v1.0) and the E. coli GSM model iML1515, pathways enriched with the AMR-associated genes that, when knocked out, significantly affected the reaction fluxes throughout the pathway. Significance was tested using hypergeometric enrichment tests (two-tailed) with the false discovery rate (FDR) threshold less than 1%. The pathway nodes (small circles) from each model are connected to the GSM model by unweighted edges. Pink nodes were significantly affected in the S. enterica model only, blue nodes in the E. coli model only and orange nodes in both models.

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