Fig. 6: Gene expression changes in methionine biosynthesis and salvage pathway influenced by the ~3 K region. | Nature Communications

Fig. 6: Gene expression changes in methionine biosynthesis and salvage pathway influenced by the ~3 K region.

From: Increase in antioxidant capacity associated with the successful subclone of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11-KL64

Fig. 6

Catalytic enzyme genes are shown in italic. Blue italics represent genes with significantly different expression, and the adjacent bar graphs show the log2 scale of the fold change (log2FC) of differentially expressed genes (DEGs) after knockout or reversal based on RNA-seq. The blue bars (Δ3 K) represent the comparison between C4599 and C4599Δ3K, the yellow bars (WT+hp1-4) represent the comparison between C1789::hp1-4 and C1789pEasy, and the red bars (WT+hp5) represent the comparison between C1789::hp5 and C1789pEasy. Wald test adjusted for multiple testing using the procedure of Benjamini and Hochberg was used to test significance, and adjusted p value < 0.05 was considered statistically significant when comparing the wildtype and its mutant. *adjusted p < 0.05, **adjusted p < 0.01, ****adjusted p < 0.0001. Source data are provided as a Source Data file. Metabolic pathway reference: https://www.kegg.jp/entry/map00270.

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