Table 1 Sample characteristics

From: Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer’s disease

 

CN Aβ− (n = 39)

CN Aβ+ (n = 33)

MCI/Dementia Aβ+ (n = 21)

p-value

Age

72.8 ± 5.06

76.6 ± 6.36

77.9 ± 7.06

0.003

Sex (female/male)

29/19

23/10

8/13

0.063

Centiloid

8.67 ± 7.12

67.6 ± 41.8

69.2 ± 32.5

<0.001

CSF GAP-43

4780 ± 2220

5570 ± 3820

5560 ± 3070

0.473

CSF p-tau181

19.1 ± 6.79

27.1 ± 13.3

31.5 ± 18.6

<0.001

Tau global SUVR

1.05 ± 0.070

1.11 ± 0.092

1.13 ± 0.137

0.002

MMSE

29.1 ± 1.05

28.6 ± 1.85

26.3 ± 2.89

<0.001

ADAS13

7.52 ± 4.14

8.35 ± 5.56

16.9 ± 8.94

<0.001

Tau-PET follow-up years

3.72 ± 1.58

2.93 ± 1.23

2.71 ± 1.42

0.014

Number of tau-PET visits

2.79 ± 1.13

2.88 ± 0.893

2.81 ± 0.928

0.491

  1. Group comparisons were assessed using ANOVAs for continuous or Chi-squared tests for categorical variables, using two-sided alpha thresholds of 0.05 without adjustments for multiple comparisons. For Continuous measures, means and standard deviations are shown, for categorical measures, absolute numbers are shown.
  2. MMSE Mini Mental State Exam, ADAS13 Alzheimer’s disease Assessment scale, CSF cerebrospinal fluid, p-tau phospho tau 181, GAP-43 growth-associated protein 43, PET positron emission tomography.
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