Fig. 6: Functional matrisome is of key importance for C. elegans longevity. | Nature Communications

Fig. 6: Functional matrisome is of key importance for C. elegans longevity.

From: Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

Fig. 6

a Epistatic effect of matrisome mutations on rIIS-mediated longevity potential. Bars represent the relative differences in mean lifespan extension (%) measured in matrisome mutants compared to wild-type animals within the same batch. b Mutation in vab-10/plectin/dystonin shortened wild-type (WT) lifespan and blocked longevity upon reduced insulin/IGF-1 receptor signaling at 20°C. c Mutation in him-4/hemicentin shortened wild-type (WT) lifespan and blocked longevity upon reduced insulin/IGF-1 receptor signaling at 20°C. d Mutations in integrin α and β suppressed daf-2(RNAi) longevity at 20°C. e Knocking down perlecan/unc-52 or integrin β/pat-3 starting at day 2 of adulthood suppressed germ cell-less (glp-1(e2141)) mediated longevity. f Summary of all matrisome and adhesome genes implicated in longevity. RNAi or genetic mutants are in italics, overexpression is in capital letters. a–f For details, statistics, and additional trials, see Supplementary Data 7.

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