Fig. 6: OLFWT exhibits unusual dynamics across multiple timescales. | Nature Communications

Fig. 6: OLFWT exhibits unusual dynamics across multiple timescales.

From: Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller

Fig. 6

a Analysis of picosecond time scale motions from TLS refinement (left, ellipsoids), final refined B-factors (middle, Cα range 10–50 blue-to-red rainbow), and multiconformer side chain fitting and refinement (right, Cα ribbon colored by B-factor with beige side chains) of 1.27Å resolution crystal structure of OLFWT (PDB code 8FRR, [https://doi.org/10.2210/pdb8FRR/pdb]). See also Supplementary Table 4. b Nano-to-microsecond timescale dynamics from MD simulations with RMSF mapped onto the structure (PDB code 4WXS, [https://doi.org/10.2210/pdb4WXS/pdb], range 0–5 blue-to-red rainbow). See also Supplementary Fig. 10. c month timescale dynamics from NMR. See also Supplementary Figs. 12, 13. Source data are provided as a Source Data file.

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