Fig. 1: Five significant non-HLA loci identified by the ever-largest Asian GWAS for systemic sclerosis. | Nature Communications

Fig. 1: Five significant non-HLA loci identified by the ever-largest Asian GWAS for systemic sclerosis.

From: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Fig. 1

a A Manhattan plot of the GWAS for systemic sclerosis (SSc) in the Japanese population. The novel risk loci are red-highlighted and SNPs with genome wide-significance (threshold p = 5.0 × 10−8; the black dotted line) are indicated by light green. b–d Regional locus zoom plots for novel single nucleotide polymorphisms (SNPs) identified by the GWAS for Japanese SSc. Each dot is colored by r2 of linkage disequilibrium (LD) with the purple-colored lead SNPs indicated with texts (chromosome position). 1428 cases and 112,599 controls were analyzed by logistic regression. Source data are provided as a Source Data file.

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