Fig. 4: An association of rs10917688 on IRF8 binding to the candidate cis-regulatory element. | Nature Communications

Fig. 4: An association of rs10917688 on IRF8 binding to the candidate cis-regulatory element.

From: GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region

Fig. 4

a Relative positions of the predicted IRF8 binding site within the candidate cis-regulatory element (cCRE) is presented. The rs10917688 with the reference (REF: C) and alternative (ALT: T) alleles are indicated. b Odds ratio (OR) of each genotype combination relative to the control genotypes CC for rs10917688 in FCGR/FCRL and CC or GC for rs11117420 in IRF8 is presented. Protective and risk genotypes are colored blue and red, respectively. Mean ORs and 95% confidence intervals are presented by black dots and blue bars, respectively. T-test was utilized and two-sided p-values were calculated. The sample number of each genotype is indicated at the bottom of the panel. Source data are provided as a Source Data file.

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