Fig. 1: Simplified scheme of SDHA maturation. | Nature Communications

Fig. 1: Simplified scheme of SDHA maturation.

From: Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners

Fig. 1

SDHA maturation requires FAD, dicarboxylate, SDHAF2, and SDHAF4. Each of these molecules makes binary interactions with SDHA, but the exact sequence of these binary interactions is not known. SDHA must have covalent FAD attached before it assembles into CII if the final protein complex is to be fully functional26,74,75.

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