Fig. 3: The rapidly-emerging adaptive immune response to the N terminus of ZmpB. | Nature Communications

Fig. 3: The rapidly-emerging adaptive immune response to the N terminus of ZmpB.

From: Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci

Fig. 3

a Violin plot showing IgG binding to the array probes representing the zinc metalloproteases ZmpA (n = 56), ZmpB (n = 56), ZmpC (n = 4) and ZmpD (n = 3). The horizontal line across the violin shows the median value of the raw data, which are represented by the individual points. Each plot shows the binding to a type of probe across all variants of the corresponding protein. No complete version of ZmpD was included on the array. b Barplot showing the type of probe stimulating the strongest IgG binding within each serum sample, categorised by the age at which the sample was taken. c Violin plot showing the binding of four capsule polysaccharide-specific human monoclonal IgG to the ZmpA (n = 57) and ZmpB (n = 58) probes on the array. The absence of any immunoreactivity in this analysis demonstrates that the high level of IgG binding to the ZmpB N terminus in the serum samples is the consequence of an adaptive immune response to a specific epitope. Source data are provided as a Source Data file.

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