Fig. 3: Scope of defluorinative coupling of ArCF3 with [1.1.1]propellanea. | Nature Communications

Fig. 3: Scope of defluorinative coupling of ArCF3 with [1.1.1]propellanea.

From: C−F bond activation enables synthesis of aryl difluoromethyl bicyclopentanes as benzophenone-type bioisosteres

Fig. 3

aIsolated yields. General reaction conditions: trifluoroarenes (0.6 mmol, 1.0 equiv.), [1.1.1]propellane (1.5 equiv.), γ-terpinene (5.0 equiv.), photocatalyst (10 mol%), base (1.2 equiv.), DMSO (0.025 M), Kessil LEDs 427 nm (40 W) for 12 h. Selection of photocatalyst & base see Supplementary Information. bPCN (1) as photocatalyst and Cs2CO3 as base. cPBN (3) as photocatalyst and CsOH·H2O as base. dPerformed with trifluoroarenes hydrochloride (0.6 mmol, 1.0 equiv.), base (2.2 equiv.). e[1.1.1]propellane (2.0 equiv.).

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