Fig. 5: Scope for the defluorinative three-component couplinga. | Nature Communications

Fig. 5: Scope for the defluorinative three-component couplinga.

From: C−F bond activation enables synthesis of aryl difluoromethyl bicyclopentanes as benzophenone-type bioisosteres

Fig. 5

aIsolated yields. General reaction conditions: trifluoromethylarenes (1.2 mmol, 1.0 equiv.), [n.1.1]propellane (1.5 equiv.), B2pin2 (3.0 equiv.), DMAP (3.0 equiv.), photocatalyst PCN (1) (10 mol%), Cs2CO3 (0.8 equiv.), MeCN (0.05 M), Kessil LEDs 390 nm (40 W) for 6 h. See Supplementary Information for full experimental details. bB2Pin2 (10.0 equiv.), w/o DMAP.

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