Table 1 Optimization of the defluorinative coupling of ArCF3 with [1.1.1]propellane

From: C−F bond activation enables synthesis of aryl difluoromethyl bicyclopentanes as benzophenone-type bioisosteres

  1. aPerformed with photocatalyst PCN (1) (10 mol%), trifluomethyl arene (5) (1.0 equiv.), [1.1.1]propellane in DMF (1.2 M, 1.5 equiv.), γ-terpinene (5.0 equiv.), Cs2CO3 (1.2 equiv.).
  2. bYield by 19F-NMR analysis of the crude reaction mixtures using PhCF3 as internal standard
Back to article page