Fig. 4: Cathepsin Z in PAH patients. | Nature Communications

Fig. 4: Cathepsin Z in PAH patients.

From: Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension

Fig. 4

a Blood RNA CTSZ levels in PAH patients divided by CTSZ CpG methylation status n = 276 patients were divided into tertiles of CpG methylation levels for comparison with mRNA levels by Kruskal–Wallis one way ANOVA. b Plasma levels of cathepsin Z in PAH versus controls, Logistic regression models used to test the effect of cathepsin Z on PAH were adjusted for age, sex, first two principal components and coagulation factor X. n = 463 PAH cases and 108 disease-free controls. Boxplots depict median, first and third quartiles (Q1/Q3 = IQR), and whiskers indicate Q1/Q3 +/− 1.5 * IQR. c Immunohistochemistry of CTSZ in PAH lung tissue. CD31 is shown as a marker for endothelium. N = 3 vs 4 control and PAH patient tissue sections. Scale bar represents 50um.

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