Fig. 3: Network mining I: identifying upstream transcriptional regulatory programs that affect MYC pathway and are associated with response to Enzalutamide. | Nature Communications

Fig. 3: Network mining I: identifying upstream transcriptional regulatory programs that affect MYC pathway and are associated with response to Enzalutamide.

From: Mechanism-centric regulatory network identifies NME2 and MYC programs as markers of Enzalutamide resistance in CRPC

Fig. 3

a Schematic representation of the changes in activity levels of molecular pathways and their upstream transcriptional regulatory programs (i.e., sub-networks) as they transition from Intact (treated with DMSO) to Enzalutamide-sensitive (EnzaSens) to Enzalutamide-resistant (EnzaRes) phenotypes. Red depicts up-regulation and blue depicts down-regulation of TR and pathway activities. b Identified upstream transcriptional regulatory programs (MYC-centered sub-network) associated with Enzalutamide treatment affecting MYC pathway, depicted across Intact, EnzaSens, and EnzaRes phenotypes. Red depicts up-regulation and blue depicts down-regulation of TR and pathway activities. Source data are provided as a Source Data file.

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