Fig. 2: Genome wide association results for TSH, FT4, FT3 and FT3/FT4 ratio. | Nature Communications

Fig. 2: Genome wide association results for TSH, FT4, FT3 and FT3/FT4 ratio.

From: Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Fig. 2

The circos plot depicts the association results for TSH, FT4, FT3 and the FT3/FT4 ratio combined: red band: –log10(p) for association in the meta-analysis of TSH, ordered by chromosomal position. The blue line indicates genome-wide significance (p = 5 × 10−8). Blue band: –log10(p) for association with FT4, ordered by chromosomal position. The red line indicates genome-wide significance (p = 5 × 10−8). Purple band: –log10(p) for association with FT3, ordered by chromosomal position. The blue line indicates genome-wide significance (p = 5 × 10−8). Green band: –log10(p) for association with the FT3/FT4 ratio, ordered by chromosomal position. The red line indicates genome-wide significance (p = 5 × 10−8). The outer band indicates the positions of the associated loci as defined in Methods. Adjacent loci for a trait with the same gene names are merged. The color follows the same pattern as the association plots of the four traits. All p-values were obtained from two-sided association tests (z-statistics), where correction for multiple testing is indicated by the level of genome-wide significance.

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