Fig. 3: Zoomed Manhattan plot for TSH and FT4. | Nature Communications

Fig. 3: Zoomed Manhattan plot for TSH and FT4.

From: Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Fig. 3

Zoomed Manhattan plot of the GWAS meta-analysis results for TSH (panel a) and FT4 (panel b). Variants are plotted on the x-axis according to their position on each chromosome with the -log10(p-value) of the association test on the y-axis. The horizontal line indicates the threshold for genome-wide significance, (p = 5 × 10−8). All p-values were obtained from two-sided association tests (z-statistics), where correction for multiple testing is indicated by the level of genome-wide significance. Novel loci are colored in orange, and novel independent associations within known loci are colored in light blue. Genetic variants were assigned to the nearest gene. Variants were considered known when they are in linkage disequilibrium with a previously identified variant (see Methods).

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