Fig. 6: Effects of genetic variants on different thyroid-related outcomes using Mendelian Randomization. | Nature Communications

Fig. 6: Effects of genetic variants on different thyroid-related outcomes using Mendelian Randomization.

From: Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Fig. 6

Twenty-four clinical outcomes were tested against the thyroid-related parameters. Significance thresholds are depicted either with a closed bubble (Bonferroni corrected) or an open bubble (nominal significance at p < 0.05). The direction of effect is depicted in color: blue shows a negative beta and red is a positive beta. The size of the bubble indicates the degree of the association in terms of -log10(p-value). All p-values were obtained from two-sided weighted median Mendelian Randomization tests. Clinical outcomes with at least one association with thyroid function parameters are depicted. Bone mineral density, anxiety, and major depressive disorder with zero associations are therefore not shown.

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