Fig. 3: Ferroptosis-resistant features and immune escape mechanisms of CCA classes. | Nature Communications

Fig. 3: Ferroptosis-resistant features and immune escape mechanisms of CCA classes.

From: A transcriptome based molecular classification scheme for cholangiocarcinoma and subtype-derived prognostic biomarker

Fig. 3

Heatmaps displaying expression levels of a genes encoding co-stimulators, co-inhibitors and MHC antigens; b ferroptosis-related genes in each molecular class. The expression values were normalized and represented by z-scores. Box plots representing c the enrichment of ferroptosis-related gene signature (GSVA applied with z-score method); d the abundance of CD4+ T memory resting cells; e the abundance of B naïve cells; f the estimation of immune compartment in each class (ESTIMATE package). Box plots show median, interquartile values, range and outliers (individual points), C1, n = 58; C2, n = 106. P values were calculated by two-sided Wilcoxon rank sum test.

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