Table 1 Univariate and multivariate analysis for overall survival

From: A transcriptome based molecular classification scheme for cholangiocarcinoma and subtype-derived prognostic biomarker

 

Univariate analysis

Multivariate analysis

Factor

Category

N (%)

HR (95% CI)

p

HR (95% Cl)

p

Age

-

-

1.02 (0.99–1.05)

0.176

  

Sex

female

45 (29.0)

-

   

Male

110 (71.0)

1.54 (0.92–2.56)

0.1

  

Anatomical location

Distal

48 (31.0)

-

 

-

 

Intrahepatic

25 (16.1)

2.20 (1.124.34)

0.022

2.05 (1.044.07)

0.039

Perihilar

82 (52.9)

1.76 (1.042.99)

0.036

1.46 (0.85–2.50)

0.166

Stage

I + IA/B + II + IIA/B

113 (72.9)

-

 

-

 

IIIA + IIIB + IIIC + IV + IVB

42 (27.1)

2.18 (1.393.42)

0.001

1.84 (1.162.92)

0.01

Differentiation

Low + Medium low

98 (63.2)

-

   

Medium + High

57 (36.8)

0.98 (0.63–1.53)

0.921

  

Molecular subtype

Metabolic & Proliferative-C2

99 (63.9)

-

 

-

 

Mesenchymal & Immunosupressive-C1

56 (36.1)

2.20 (1.433.38)

<0.001

2.02 (1.303.12)

0.002

  1. The p values are two-sided and p < 0.05 was considered significant. Clinical factors with a p < 0.05 (considered significant) in both univariate and multivariate analysis were highlighted by bold style.
  2. CI confidence interval, HR hazard ratio.