Fig. 7: VGLL1/TEAD4 cooperate with GATA3 and TFAP2C to regulate TE identity.
From: VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification
a Venn diagram showing the pairwise overlap between VGLL1-, TEAD4-, GATA3- and TFAP2C-bound sites in 4CL H9 ESC-derived TELC-D5 cells. b Four-way venn diagram showing the overlap between VGLL1-, TEAD4-, GATA3-, and TFAP2C- bound sites in 4CL H9 ESC-derived TELC-D5 cells. c Enriched GO terms for genes in Group 1 of panel b. P value was calculated using a hypergeometric test (one-sided) and adjusted for multiple testing using the Benjamini-Hochberg correction. d Enriched GO terms for genes in group 2 of panel b. P value was calculated using a hypergeometric test (one-sided) and adjusted for multiple testing using the Benjamini-Hochberg correction. e Motif analysis using HOMER showing the significantly enriched DNA-binding motifs at GATA3-binding sites in 4CL H9 ESC-derived TELC-D5 cells. P value was calculated using a hypergeometric test (one-sided). f Motif analysis using HOMER showing the significantly enriched DNA-binding motifs at TFAP2C-binding sites in 4CL H9 ESC-derived TELC-D5 cells. P value was calculated using a hypergeometric test (one-sided). g Genome browser tracks showing VGLL1, TEAD4, GATA3 and TFAP2C binding in 4CL H9 ESC-derived TELC-D5 cells for representative TE loci.
