Fig. 2: Results of the model screening process.
From: Rational strain design with minimal phenotype perturbation
a We filtered the 800,000 putative kinetic models down to 10 models that possessed the desired linearized dynamic characteristics, reproduced experimentally observed fermentation curves, and proved robust to enzymatic perturbations. b–d Comparison of the simulated growth (b), anthranilate (c), and glucose (d) responses of the 10 models with experimental batch fermentation data. The orange solid line and the shaded region represent the median and the interquartile range of the simulated responses respectively. The solid circles and error bars are the mean and standard deviation from the triplicate experiments. The behavior of the 10 kinetic models under batch fermentation conditions showed close agreement with the experimental data. Source data are provided as a Source Data file.
