Table 1 Associations between smoking status and inflammatory bowel disease

From: Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease

 

Crohn’s disease (cases, n = 1770)

Ulcerative colitis (cases, n = 2889)

Crude model*

Fully adjusted#

Crude model*

Fully adjusted#

HR (95%CI)

P

HR (95%CI)

P

HR

P

HR

P

Never smoking

ref

 

ref

 

ref

 

ref

 

Ever smoking

1.51 (1.37, 1.65)

<2 × 10−16

1.49 (1.31, 1.69)

5.83 × 10−10

1.45 (1.34, 1.56)

<2 × 10−16

1.51 (1.37, 1.66)

<2 × 10−16

Previous smoking

1.39 (1.25, 1.54)

5.06 × 10−10

1.41 (1.23, 1.61)

7.00 × 10−7

1.54 (1.42, 1.66)

<2 × 10−16

1.59 (1.44, 1.76)

<2 × 10−16

Current smoking

1.88 (1.64, 2.16)

<2 × 10−16

1.81 (1.50, 2.19)

7.09 × 10−10

1.15 (1.01, 1.30)

0.038

1.18 (1.00, 1.39)

0.051

Pack years

<= 20

ref

 

ref

 

ref

 

ref

 

20 − 40

1.05 (0.88, 1.25)

0.623

1.10 (0.88, 1.38)

0.393

1.12 (0.98, 1.29)

0.107

1.09 (0.92, 1.29)

0.313

40 − 60

1.22 (0.98, 1.51)

0.070

1.34 (1.02, 1.75)

0.036

1.08 (0.91, 1.29)

0.396

1.08 (0.87, 1.33)

0.485

 > 60

1.03 (0.81, 1.32)

0.805

1.15 (0.85, 1.55)

0.372

1.12 (0.93, 1.35)

0.235

1.05 (0.83, 1.31)

0.703

Age of stopping smoking

<= 30

ref

 

ref

 

ref

 

ref

 

30 − 40

1.24 (0.98, 1.58)

0.079

1.35 (1.00, 1.81)

0.046

1.18 (0.99, 1.40)

0.069

1.14 (0.93, 1.41)

0.214

40 − 50

1.17 (0.90, 1.52)

0.232

1.26 (0.90, 1.75)

0.178

1.32 (1.10, 1.58)

2.72 × 10−3

1.40 (1.12, 1.75)

0.003

 > 50

1.89 (1.46, 2.43)

9.49 × 10−7

1.79 (1.29, 2.50)

0.001

1.50 (1.24, 1.81)

2.59 × 10−5

1.48 (1.16, 1.87)

0.001

  1. *, the crude model was adjusted for age and sex. #, the fully adjusted model was adjusted age, sex, BMI, drinking status, physical activity, processed meat, body mass index, education level, and the first 10 genetic principal components. Cox regression model was used to evaluate the association between smoking status and IBD. All tests were two-sided and P < 0.05 was considered as significant. Source data are provided as a Source Data for Tables 1, 2 and Supplementary data7 (CD analysis) and Source Data for Tables 1, 2 and Supplementary Data 7 (UC analysis).
  2. HR hazard ratio, CI confidence interval.