Table 1 Associations between smoking status and inflammatory bowel disease
Crohn’s disease (cases, n = 1770) | Ulcerative colitis (cases, n = 2889) | |||||||
---|---|---|---|---|---|---|---|---|
Crude model* | Fully adjusted# | Crude model* | Fully adjusted# | |||||
HR (95%CI) | P | HR (95%CI) | P | HR | P | HR | P | |
Never smoking | ref | ref | ref | ref | ||||
Ever smoking | 1.51 (1.37, 1.65) | <2 × 10−16 | 1.49 (1.31, 1.69) | 5.83 × 10−10 | 1.45 (1.34, 1.56) | <2 × 10−16 | 1.51 (1.37, 1.66) | <2 × 10−16 |
Previous smoking | 1.39 (1.25, 1.54) | 5.06 × 10−10 | 1.41 (1.23, 1.61) | 7.00 × 10−7 | 1.54 (1.42, 1.66) | <2 × 10−16 | 1.59 (1.44, 1.76) | <2 × 10−16 |
Current smoking | 1.88 (1.64, 2.16) | <2 × 10−16 | 1.81 (1.50, 2.19) | 7.09 × 10−10 | 1.15 (1.01, 1.30) | 0.038 | 1.18 (1.00, 1.39) | 0.051 |
Pack years | ||||||||
<= 20 | ref | ref | ref | ref | ||||
20 − 40 | 1.05 (0.88, 1.25) | 0.623 | 1.10 (0.88, 1.38) | 0.393 | 1.12 (0.98, 1.29) | 0.107 | 1.09 (0.92, 1.29) | 0.313 |
40 − 60 | 1.22 (0.98, 1.51) | 0.070 | 1.34 (1.02, 1.75) | 0.036 | 1.08 (0.91, 1.29) | 0.396 | 1.08 (0.87, 1.33) | 0.485 |
> 60 | 1.03 (0.81, 1.32) | 0.805 | 1.15 (0.85, 1.55) | 0.372 | 1.12 (0.93, 1.35) | 0.235 | 1.05 (0.83, 1.31) | 0.703 |
Age of stopping smoking | ||||||||
<= 30 | ref | ref | ref | ref | ||||
30 − 40 | 1.24 (0.98, 1.58) | 0.079 | 1.35 (1.00, 1.81) | 0.046 | 1.18 (0.99, 1.40) | 0.069 | 1.14 (0.93, 1.41) | 0.214 |
40 − 50 | 1.17 (0.90, 1.52) | 0.232 | 1.26 (0.90, 1.75) | 0.178 | 1.32 (1.10, 1.58) | 2.72 × 10−3 | 1.40 (1.12, 1.75) | 0.003 |
> 50 | 1.89 (1.46, 2.43) | 9.49 × 10−7 | 1.79 (1.29, 2.50) | 0.001 | 1.50 (1.24, 1.81) | 2.59 × 10−5 | 1.48 (1.16, 1.87) | 0.001 |