Fig. 4: Sox2+/Sox10+ cells are located at the base of the Meissner corpuscle. | Nature Communications

Fig. 4: Sox2+/Sox10+ cells are located at the base of the Meissner corpuscle.

From: Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception

Fig. 4

a Schematic of the localization of Sox2 at mechanoreceptor endings. b Upper panels show a lower magnification immunohistochemistry for TOMATO (recapitulating Sox2 expression) and S100β to label glial cells in glabrous skin of Sox2-TOM hind paws. Arrowheads point to Meissner corpuscles. Lower panels show a high magnification image of an immunohistochemistry for TOMATO (recapitulating Sox10 expression), PGP9.5 to label neurons in the corpuscle sensory ending and against Sox2. Arrowhead points to a Sox2+/Sox10+ cell within the Meissner corpuscle. Scale bar: 50 μm (upper panel) and 20 μm (lower panel). Immunohistochemistry experiments were repeated at least 3 times with similar results.

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