Fig. 7: Kp-10 ameliorated OVX-induced bone loss. | Nature Communications

Fig. 7: Kp-10 ameliorated OVX-induced bone loss.

From: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src

Fig. 7

a, c Representative micro-CT images of femoral trabecular bone (a) and cortical bone (c). Female C57 mice treated with vehicle (Sham) or 50 nmol/kg (DSS)*6-Kp-10, ovariectomized mice (OVX) treated with vehicle or 50nmol/kg (DSS)*6-Kp-10 twice one week by intraperitoneal injection (n = 6 per group). Scale bar, 500 µm. b, d Parameter analysis of femurs from the mice above. BMD bone mineral density, BV/TV bone volume as a fraction of total bone volume, Tb.Th trabecular thickness, Tb.N trabecular number, Tb.Sp trabecular separation. e Representative TRAP staining images of femurs from Fig. 7a. f Histomorphometry analysis of the femurs from Fig. 7a. Oc.S/BS osteoclast surface per bone surface, N.Oc/B.Pm osteoclast bone surface density, ES/BS eroded surface per bone surface. Data represent means ± SEM. P values were determined by one-way ANOVA analysis (b, d, f). Representative results were obtained from at least three independent experiments. Source data are provided as a Source Data file.

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