Fig. 7: Stress dependent positive and negative regulation of DREB2A. | Nature Communications

Fig. 7: Stress dependent positive and negative regulation of DREB2A.

From: Molecular switching in transcription through splicing and proline-isomerization regulates stress responses in plants

Fig. 7

A Bivalent DREB2A interaction region, produced under non-stress conditions, forms a complex with Med25-ACID using both the ABS and the RIM, whereas the high-affinity RCD1-RST interaction is driven by the RIM. The ABS interaction with Med25 scaffolds the mediator complex while proline-dependent frustration of the RIM may promote binding of additional co-regulators. B Heat stress induced synthesis of a DREB2A splice variant lacking the RIM (and AD1) is unable to bind RCD1-RST but retains the ability to scaffold mediator through the ABS and activate transcription through AD2. Affinities are given at 25 °C while kinetic rate constants are given at 10 °C.

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