Fig. 2: Positive and negative speed modulation of interneuron activity.
From: Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
a Calcium activity (peak-normalized) over animal running speed for PV- and SOM-INs in CA1 (top), CA2/3 (middle) and DG (bottom). Color code denotes significance of speed modulation (red = positive, blue = negative, gray = no significant speed modulation) for individual cells. b Fraction of cells with significant positive (red), negative (blue) or no (gray) speed modulation for the individual IN types and hippocampal areas. c Distribution of slopes for speed modulation obtained by a linear fit to the data (see Fig. 1f, j blue dotted line) for PV-cells (dark colors) and SOM-cells (light colors) in the three hippocampal areas. d Ratio of activity-rates between phases of moving and immobility for PV-cells (dark colors) and SOM-cells (light colors) in the three hippocampal areas. Vertical markup denotes significance of the paired comparison of moving vs. immobile activity (Wilcoxon signed rank test). p values between groups (horizontal) in c, d represent Kruskal–Wallis- with Dunn’s post hoc test. Lines represent median and interquartile ranges, dots represent data from individual cells. NS not significant; ***p < 0.001. All statistical tests are two-sided. For exact p values and comparisons between all groups see Supplementary Table 2.
