Fig. 7: Context-dependent remapping is differentially affected by SOM and PV interneurons.

a Activity maps of GC place cells are shown with the same sorting on the familiar (FAM; left plot of the group) and novel (NOV; right plot) track. Data are shown separately for cells with familiar context place fields during baseline conditions (bsl; left group, blue shading) and after clozapine injection (clz; right group, orange shading) in PV-Cre mice transfected with floxed h4MDi. b Correlations of spatial activity profiles (‘place fields’) between familiar and novel environments before (bsl F/N; left, blue) and after (clz F/N; right, orange) suppression of DG PV-IN activity via h4MDi. Note, decrease in place field correlations between familiar and novel environments after DG PV-INs silencing. c, d Same as in a and b but before (left, blue) and after (right, orange) disruption of DG SOM-IN activity through clozapine injection in SOM-Cre mice transfected with floxed hM4Di. Note, increase in place field correlations between familiar and novel environments after DG SOM-IN silencing. e, f Same as in a and b but for control PV- and SOM-Cre mice expressing an inert mCherry construct. Note, no changes in GC activity correlations between contexts were induced by clozapine alone. b, d, f Wilcoxon rank-sum test. NS not significant, *p < 0.05. All statistical tests are two-sided. For exact p-values see Supplementary Table 2.