Fig. 8: Effects of hippocampal PV and SOM interneurons in familiar and novel environments.
From: Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
a Schematic summary of interneuron activities and effects in the familiar environment. Green cells represent PV-INs, pink cells SOM-INs, red- and black cells depict DG GCs and hippocampal pyramidal cells, respectively. Green axon in the molecular layer illustrates perforant-path axons from the entorhinal cortex. Opacity of symbols indicates strength of activation. Relatively weak activation allows for stronger recruitment of DG GCs, while relatively stronger activation of other hippocampal neuron types keeps CA1-3 principal activation at bay. b Same as in a, but for novel environments. Increased activity of DG SOM-INs reduces the activation of other DG cell types, while relatively weaker activation of most other hippocampal IN classes may allow for stronger direct recruitment of pyramidal cells through the perforant path.
