Fig. 7: Illustration summary of CUL5 regulation of CD8+ T cell anti-tumor responses. | Nature Communications

Fig. 7: Illustration summary of CUL5 regulation of CD8+ T cell anti-tumor responses.

From: The CUL5 E3 ligase complex negatively regulates central signaling pathways in CD8+ T cells

Fig. 7

The CUL5 protein and its neddylation are significantly upregulated upon TCR stimulation, which at least partially serves as a potential negative feedback regulator of TCR/IL2 signaling and anti-tumor effector activity in CD8+ T cells. CUL5 KO in CD8+ T cells significantly enhances their effector function, TCR and cytokine signaling, stemness, and survival accompanied with improved tumor control ability. The icons are created with BioRender.com.

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